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More patients demand ‘unvaccinated’ blood, doctors warn of growing health risks
An increasing number of patients are requesting “unvaccinated” blood for transfusions, which can delay care and pose risks to patients’ health, experts warn.
There is no evidence that unvaccinated blood presents any safety benefit, according to a new study published in the journal Transfusion.
There is currently no process for checking whether donated blood comes from vaccinated or unvaccinated donors, experts say.
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Vanderbilt University in Tennessee, which conducted the research, received 15 requests for unvaccinated blood between Jan. 1, 2024, and Dec. 31, 2025. The median age of patients was 17 years old and more than half were children, the university reported.
Thirteen of the patients received blood donated specifically for them by family members, which is known as “direct donation.” This can be risky, because most direct donors are giving blood for the first time, and their donations are more likely to contain “potentially harmful pathogens,” the authors noted.
“Despite being framed as ‘safer,’ directed donations may paradoxically increase risk.”
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Among the studied patient group, two became much sicker after refusing a standard blood transfusion.
One patient developed anemia, a condition where the body lacks enough healthy red blood cells to carry adequate oxygen. The other developed hemodynamic shock, a serious condition in which there is insufficient blood flow and oxygen to the body’s tissues, potentially leading to organ failure.
Requests for unvaccinated blood spiked after the approval of COVID-19 vaccines, posing a “recurring challenge for transfusion services and clinicians,” the researchers stated.
“These requests were associated with care delays, escalation and inefficiencies,” they indicated.
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The researchers recommend that health systems create standardized policies to handle these types of requests.
“Regulatory and professional organizations have opposed these non-evidence-based policies, emphasizing that blood centers do not record or convey donor COVID-19 vaccination status and that evidence demonstrates transfusion from vaccinated donors poses no unique risk.”
The Vanderbilt study had some limitations, the researchers noted. It looked at a small number of cases and only included situations where special blood donations made it to the blood bank, so it doesn’t show how often people made this request overall.
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It also didn’t include cases where concerns were resolved through conversations with doctors or ethics teams, the team noted.
As this was an observational study and not a controlled experiment, it only showed an association and could not prove that refusing standard blood directly caused any specific patient outcomes.
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Several states have introduced proposals aimed at allowing patients to receive blood specifically from donors who have not received COVID-19 vaccines.
In Oklahoma, one such proposal called for the creation of a state-run blood bank dedicated to collecting and distributing blood from unvaccinated donors. Despite these efforts, none of the measures have been enacted into law.
Dr. Marc Siegel, Fox News senior medical analyst, was not involved in the research, but said these types of requests are “part of an ongoing fear culture.”
“It is also very difficult to test for, because the antibodies may be positive from COVID itself as well as the vaccine, and it can be difficult to tell the difference,” he told Fox News Digital.
The notion that receiving blood from someone who had the vaccine would be harmful is not based on any scientific studies, the doctor reiterated.
“If people want to group up to get blood from other unvaccinated people, I respect that choice, though it will be expensive and will limit options,” Siegel added.
Diane Calmus, vice president of government affairs for America’s Blood Centers in Washington, D.C., said that requests for direct donations are “exceedingly rare” – representing about 0.06% of the U.S. blood supply.
“Requests for unvaccinated blood are something we’ve seen wax and wane since the introduction of the COVID vaccine,” Calmus, who also was not involved in the Vanderbilt study, told Fox News Digital. “The challenge is that there’s no way to tell whether someone’s blood has been vaccinated – there’s no test that exists.”
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Any situation where someone requires a blood transfusion is most likely a “very scary time,” she noted.
“Family members want to be cautious, and this is why it’s so important that people talk to a transfusion medicine-trained doctor,” the expert advised. “These are physicians who have a specialty in blood transfusions … and who can answer those questions that any individual will have.”
Calmus pointed out that it takes some time to facilitate a direct donation, and that there is a specific process in place.
“Blood has to be prescribed. You can’t just show up at the blood center and say, ‘I would like my sister to donate for me,’” she said. “There needs to be a prescription. It needs to go through the hospital … they need to make sure it is the right blood for the right patient.”
Calmus emphasized that the U.S. blood supply is “meticulously tracked,” and that there have been no indications of a lack of safety. She also stressed the ongoing need for blood donors.
“We need people – vaccinated or not vaccinated – to show up and donate blood, because it is the blood on the shelves that saves lives.”
Fox News Digital reached out to the Vanderbilt researchers for comment.
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Pope Leo says he’s unafraid of the Trump admin after president calls him ‘terrible’ on foreign policy
Pope Leo XIV fired back after President Donald Trump attacked him on social media, saying his calls for peace are rooted in the Gospel and should not be treated as a political argument with the White House.
“I have no fear of the Trump administration,” the pope told reporters aboard the papal plane Monday en route to Algeria.
“The message of the church, my message, the message of the Gospel: Blessed are the Peacemakers. I do not look at my role as being political, a politician,” he added.
Trump had criticized the pope’s positions on Sunday in a scathing rebuke on Truth Social.
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“Pope Leo is WEAK on Crime, and terrible for Foreign Policy,” Trump began in a lengthy post.
“Leo should get his act together as Pope, use Common Sense, stop catering to the Radical Left, and focus on being a Great Pope, not a Politician. It’s hurting him very badly and, more importantly, it’s hurting the Catholic Church,” he concluded.
The pope responded Monday, taking a shot at Trump’s Truth Social – “it’s ironic, the name of the site itself; say no more” – despite claiming “I will not enter into debate.”
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“The things that I say are certainly not meant as attacks on anyone,” he also said, speaking in English, adding, “I don’t think that the message of the Gospel is meant to be abused in the way that some people are doing. I will continue to speak out loudly against war, looking to promote peace, promoting dialogue and multilateral relationships among the states to look for just solutions to problems.”
“Too many people are suffering in the world today,” Leo added. “Too many innocent people are being killed. And I think someone has to stand up and say there’s a better way.”
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The pope’s stance against Trump’s peace efforts in the Middle East came after the president’s Sunday night Air Force One tarmac comments.
“We don’t like a pope that’s going to say that it’s okay to have a nuclear weapon,” Trump told reporters, echoing remarks from the Truth Social post. “We don’t want a pope that says crime is okay in our cities. I don’t like it.”
“I’m not a big fan of Pope Leo. He’s a very liberal person, and he’s a man that doesn’t believe in stopping crime,” Trump added. “He’s a man that doesn’t think that we should be toying with a country that wants a nuclear weapon so they can blow up the world.”
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Leo claimed he was speaking for the church and not himself or Iran.
“To put my message on the same plane as what the president has attempted to do here, I think is not understanding what the message of the Gospel is,” Leo said. “And I’m sorry to hear that but I will continue on what I believe is the mission of the church in the world today.”
Trump claimed Leo has him to thank for being elevated to pope, the first American pope.
“I like his brother Louis much better than I like him, because Louis is all MAGA,” Trump wrote in his Truth Social post. “He gets it, and Leo doesn’t.”
“If I wasn’t in the White House, Leo wouldn’t be in the Vatican,” Trump said.
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Ex-NFL first-round pick suffers season-ending knee injury while attempting pro comeback in arena league
The Denver Broncos took a flyer on quarterback Paxton Lynch during the 2016 NFL Draft, selecting him in the first round that year in one of the event’s biggest shockers.
However, the former Memphis Tigers standout would only play five NFL games before he bounced around the league from practice squad to practice squad. He was last seen on the Pittsburgh Steelers’ roster in 2020.
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Lynch was attempting to find a route back into the NFL and landed with the Colorado Spartans of the National Arena League before the 2026 season. He was in his third game with the Spartans when he suffered a torn LCL.
“I was p—ed off,” he told The Denver Post. “And it sucks. I didn’t want it to be like this.”
Lynch appeared to take solace in being able to play again – even if it was in an indoor football league. He suggested he was up for the challenge.
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“I was like, ‘OK, if I play this year in arena football, I’m going to play as Paxton Lynch. I’m going to have full confidence in myself. I don’t really care.’ And that’s what I did,” he told the paper.
“It felt good to do that again.”
He had three touchdown passes in three games with Colorado. Javin Kilgo replaced him at quarterback. Through five games, Colorado is 2-3.
Lynch told The Denver Post he wasn’t sure if he would play in 2027, but if the National Arena League is where his career ended, he said he was just fine with that.
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Discovery at Monticello reveals construction secrets Thomas Jefferson left out of maps and letters
Archaeologists have uncovered a previously unknown remnant of Thomas Jefferson’s era at Monticello: a brick kiln used to build his home.
The kiln was recently found on the east side of the Founding Father’s home amid an excavation that began in March, officials said.
Monticello historians believe it dates back to the early 1770s — some time before Jefferson wrote the Declaration of Independence in 1776.
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It was part of the construction of Monticello I, the first version of Jefferson’s home.
The current structure reflects a later rebuild and expansion completed after his time in France, after 1789.
Photos from the site show researchers working around a rectangular dig at Monticello, exposing evenly spaced brick channels and revealing several bricks stamped with initials.
The kiln was a large, temporary oven used to harden bricks, said Crystal O’Connor, manager of archaeological field research at Monticello.
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O’Connor told Fox News Digital that archaeologists found brick channels “filled with overcooked brick rubble, and the soil beneath them had been baked hard by intense heat.”
Archaeologists “immediately started hitting brick, and uncovered a series of low parallel brick walls, evenly spaced about a foot and a half apart, with channels running between them,” she said.
“While the team and I weren’t sure of what we were looking at initially, that pattern is a telltale sign of a brick kiln,” O’Connor added.
Workers once stacked thousands of unfired bricks atop the kiln and kept fires burning for several days until the bricks, eventually used to build Monticello, hardened.
“When the firing was done, workers took the kiln apart and carried the finished bricks to the house,” said O’Connor.
She added, “This kiln was crucial to building the home of the author of the Declaration of Independence.“
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O’Connor noted that it was likely run by George Dudley or William Bishop, two White workmen who were hired by Jefferson — and that it relied heavily on slave labor.
Though Jefferson wasn’t making the bricks by hand, the Virginia statesman was certainly aware of the kiln’s existence.
“Jefferson knew about this work because he contracted with his brickmakers for a set number of bricks before each major building campaign,” O’Connor said.
“He would not have overseen the firings himself. Dudley or Bishop would have managed that process.”
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O’Connor said records show Jefferson calculated whether hauling finished bricks uphill or producing them on site was more efficient in late 1774.
“We wonder if the brickmakers themselves pointed out the problem of dragging barrels of water and loads of firewood uphill, and if that helped push Jefferson to do the math and move the work downhill, closer to the raw materials,” she added.
O’Connor noted that “very few” artifacts were found at the site, other than bricks — but 18th-century remnants were interesting nonetheless.
These included “several bricks shaped in special molds to match the design of the house.”
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“These are decorative bricks with curved and S-shaped profiles,” said O’Connor. “Jefferson used them in the exterior brickwork of the dining room wall, which dates to around 1772.”
She added, “They don’t appear anywhere else on the house and represent a crazy amount of customization. Finding them in the rubble next to the kiln is what tells us it dates to the early 1770s.”
The official stressed the importance of archaeology at Monticello, especially because the kiln was entirely unrecorded in Jefferson’s maps, drawings, notes and letters.
“The discovery has already changed how we understand the building of Monticello,” she said.
“Even at one of the best-documented historic sites in America, archaeology keeps revealing what the written record does not.”
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